The Semeli Hotel Mykonos is located very near the central area of Mykonos Town and on the southeastern side of Mykonos Island. Like other high-end hotels in Mykonos, it is found nearby familiar Mykonos sights like pebblestone streets, vigorous nightlife and high-end restaurants. The onsite restaurant serves a buffet breakfast and allows visitors to eat inside or on the veranda, which offers scenic views of the town and nearby sea. Other amenities include a small chapel, a swimming pool with pool bar, a gym and a cocktail lounge. The Semeli Hotel Mykonos is located in Rochari, Mykonos in Greece. It is just two kilometers from the airport and less than one kilometer from the port.

Guests staying at the Semeli Hotel Mykonos can look forward to a mini bar, double-paned glass windows, a balcony, air conditioning, cable TV, free movies, music channels, and a safe.

The Semeli Hotel Mykonos features decor that is complementary to the colors of surrounding nature and that is also respectful to Mykonos traditional architecture and design. The hotel was renovated in 2008 and modernized without losing any of its distinctive touches. The hotel rents out 48 double rooms, three triple rooms, one family room and three suites across five different buildings.